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WEDNESDAY 16 JULY Organiser: |
Professor Ana Maria Sebastiao, University of Lisbon, Portugal |
Chair: |
Professor Ana Maria Sebastiao, University of Lisbon, Portugal |
9:30 |
GPCR dimerisation: Molecular basis and relevance for function and pharmacology |
| Professor Graeme Milligan, University of Glasgow, UK | |
10:00 |
Elevated talk: The GABAB receptor agonist, baclofen, and the positive allosteric modulator, |
| CGP7930, inhibit visceral pain-related responses to colorectal distension in rats | |
| Dr Vicente Martinez, AstraZeneca. UK | |
10:15 |
The two state dimer model for G-protein-coupled receptors: new perspectives for academic |
| research and for drug development | |
| Professor Rafael Franco, University of Barcelona, Spain | |
10:45 |
Coffee break |
11:15 |
Dopamine D1-D2 receptor heterooligomerization and its regulation |
| Dr Melissa Perreault, University of Toronto, Canada | |
11:45 |
Elevated talk: TNF-alpha regulation of proteinase-activated receptor-2 and -4 |
| heterodimerisation | |
| Ms Margaret Cunningham, University of Strathclyde, UK | |
12:00 |
Cross Talk between Tyrosine Kinase Receptors and GPCRs |
| Professor Ana Maria Sebastiao, University of Lisbon, Portugal | |
12:30 |
End of symposium |
Organisers: |
Gillian Edwards, University of Manchester, UK |
| Professor Martial Ruat, CNRS, France | |
Chairs: |
Gillian Edwards, University of Manchester, UK |
| Professor Martial Ruat, CNRS, France | |
9:30 |
Calcium, Allosteric Modulators and Calcium Sensing Receptor Activity |
| Professor Martial Ruat, CNRS, France | |
10:00 |
Elevated talk: Insights into Class III GPCR function from studies of the TIR taste receptor family |
| Dr Graeme Conn, University of Manchester, UK | |
10:15 |
Calcium Sensing Receptors in the Vasculature: Pharmacology and Functions |
| Professor Arthur Weston, University of Manchester, UK | |
10:45 |
Coffee break |
11:15 |
Elevated talk: Amino acids and the rat mesenteric arterial calcium-sensing receptor |
| Ms Annie Geraghty, University of Manchester, UK | |
11:30 |
Characterization of GPRC6A - a 7TM receptor activated by L-a-amino acids and positively |
| modulated by divalent cations | |
| Professor Hans Brauner-Osborne, Danish University of Pharmaceutical Sciences, Denmark | |
12:00 |
Calcimimetics for Hyperparathyroidism in Patients Receiving Haemodialysis |
| Professor Tilman B Drueke MD, Necker Hospital, France | |
12:30 |
End of symposium |
Organiser: |
Dr Bastian Hengerer, Boehringer Ingelheim, Germany |
Chair: |
Dr Bastian Hengerer, Boehringer Ingelheim, Germany |
9:30 |
Present Understanding in Mechanisms of Neuro-degeneration in Parkinson's Disease |
| TBC | |
10:00 |
Elevated talk: Behavioral tests to reveal long-term functional benefit of potentially |
| neuroprotective compounds in cerebral ischemia in mouse | |
| Dr Virginie Beray-Berthat, University Paris Descartes, France | |
10:15 |
Non-Human Primate Models of Motor and Non-Motor Symptoms of Parkinson’s Disease |
| Prof. Erwan Bezard, University of Bordeaux 2, France | |
10:45 |
Coffee break |
11:15 |
Cell Models of Genetic Parkinson’s Disease for Testing Neuroprotective Therapeutic Agents |
| Prof. Christopher Ross, Johns Hopkins University, USA | |
11:45 |
Elevated talk: Effect of L-carnitine on mitochondrial antioxidants and nucleic acids in the |
| substantia nigra of 1-methyl-4-phenyl-1,3,4,6-tetrahydropyridine induced neurotoxicity in | |
| aged albino rats | |
| Dr Ponnusamy Kumar, International Medical University, Malaysia | |
12:00 |
Exogenous Modulation of Adult Neurogenesis in Preclinical Models of Parkinson’s Disease |
| Prof. Jürgen Winkler, University of Regensberg, Germany | |
12:30 |
End of symposium |
| Supported by Boehringer Ingelheim | |
Organisers: |
Paul M Vanhoutte, University of Hong Kong, China |
| Michel Félétou, Institut de Recherche Servier, France | |
Chairs: |
Prof. Stefano Taddei, University of Pisa, Italy |
| Michel Félétou, Institut de Recherche Servier, France | |
9:30 |
Uridine adenosine-tetraphosphate: A novel endothelium-derived vasconstrictive mediator |
| Joachim Jankowski, Charite-Universitaetsmedizin Berlin, Germany | |
10:00 |
Elevated talk: Modulation of sphingolipid metabolism orchestrates vascular contractility in |
| isolated carotid arteries from spontaneously hypertensive rats | |
| Mr Leon J.A Spijkers, VU Medical Centre, The Netherlands | |
10:15 |
Endothelium-dependent contractions and the prostanoid TP and IP receptors |
| MichelFéléto, Institut de Recherche Servier, France | |
10:45 |
Coffee break |
11:15 |
Endothelium-Dependent Contractions and Endothelial Dysfunction in Human Essential |
| Hypertension | |
| Professor Stefano Taddei, University of Pisa, Italy | |
11:45 |
Elevated talk: Long-term treatment with ouabain induces endothelial dysfunction that |
| increases the vasoconstriction to noradrenaline of mesenteric resistance arteries | |
| Ms Camilla Wenceslau, University of Sao Paulo, Brazil | |
12:00 |
Endothelin Receptor Antagonists and Cardiovascular Diseases |
| Prof David J Webb, University of Edinburgh, UK | |
12:30 |
End of symposium |
Organiser: |
Pavel Anzenbacher, Palacky University, Czech Republic |
9:30 |
Immunoregulatory role of histamine |
| Dr C A Akdis, Swiss Institute of Allergy and Asthma Research (SIAF), Switzerland | |
10:00 |
Elevated talk: Lymphocyte trafficking at resolution is mediated by PGD2, via iNOS |
| nitroslyation of COX-2 | |
| Ms Justine Newson, The Rayne Institute, UK | |
10:15 |
Intolerance to Tolerability. Data Intensive Early Phase Drug Studies in Man - the Key to |
| Translational Development | |
| Dr Adam Cohen, Leiden University, The Netherlands | |
10:45 |
Coffee break |
11:15 |
Cytokine blockade: a major movement in translational medical research |
| Dr Marc Feldmann, Imperial College, UK | |
11:45 |
Elevated talk: A Critical Role for the Anti-Inflammatory Protein Annexin A1 in Microglial |
| Phagocytosis | |
| Dr Simon McArthur, Imperial College London, UK | |
12:00 |
Screening for cytokine-stimulatory potential of drugs - why and how |
| Dr Zdenek Zidek, Academy of Sciences, Czech Republic | |
12:30 |
End of symposium |
