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THURSDAY 17 JULY | Organiser: | Prof Eeva Moilanen, University of Tampere, Finland |
9:30 |
The serotonin transporter in pulmonary arterial hypertension |
| Professor Margaret MacLean, University of Glasgow, UK | |
10:00 |
Elevated talk: The effects of gender on the development of pulmonary arterial hypertension in |
| mice over-expressing the serotonin transporter | |
| Dr Yvonne Dempsie, University of Glasgow, UK | |
10:15 |
Transporters in the cardiovascular system: physiological and pharmacological functions |
| Prof. Heyo K Kroemer, Ernst Moritz Arndt University, Germany | |
10:45 |
Coffee break |
11:15 |
Impact of OATP Transporters on Drug Disposition |
| Dr Mikko Niemi, University of Helsinki, Finland | |
11:45 |
Elevated talk: The effect of SLCO1B1 polymorphism on repaglinide pharmacokinetics is |
| independent of repaglinide dose | |
| Dr Annikka Kalliokoski, University of Helsinki, Finland | |
12:00 |
Drug Transporters in the Human Blood-Placental Barrier |
| Professor Kirsi Vahakangas, University of Kuopio, Finland | |
12:30 |
End of symposium |
Organiser: |
Prof Martina Schmidt, University of Groningen, The Netherlands |
Chair: |
Prof Martina Schmidt, University of Groningen, The Netherlands |
9:30 |
The regulation and function of Epac proteins |
| Mr Martijn Gloerich, UMC Utrecht, The Netherlands | |
10:00 |
Elevated talk: Lipid Raft-mediated transmembrane signalling associated with lysosomal |
| targeting and trafficking of acid sphingomyelinase in endothelial cell membrane | |
| M Prof. Pin-Lan Li, Virginia Commonwealth University, USA | |
10:15 |
Compartmentalized cAMP Signalling in Cardiac Myocytes |
| Dr Manuela Zaccolo, University of Glasgow, UK | |
10:45 |
Coffee break |
11:15 |
Regulation of Anti-Inflammatory Signalling by Epac in Vascular Endothelial Cells |
| Dr Stephen Yarwood, University of Glasgow, UK | |
11:45 |
Elevated talk: E Lipoxin A4 levels in asthma: Relation with disease severity and aspirin sensitivity |
| Prof. Mehmet Melli, Ankara University, Turkey | |
12:00 |
Epac: effectors and biological functions in the heart and lung |
| Prof Martina Schmidt, University of Groningen, The Netherlands | |
12:30 |
End of symposium |
Organiser: |
Izaak Den Daas, Xendo Drug Development B.V, The Netherlands |
9:30 |
Molecular Imaging of gene expression in the living subject: pre-clinical applications |
| in biotherapies | |
| Dr Georges Vassaux, Institut des Maladies de l’Appareil Digestif 1, France | |
10:00 |
Elevated talk: The serotonin-1B receptor: a novel target for the pathophysiology of depression |
| Dr Zubin Bhagwagar, Yale University, USA | |
10:15 |
Positron Emission Tomography: the Conceptual Idea Using a Multi Disciplinary Approach |
| Dr Anne M.J Paans, University Medical Centre Groningen, The Netherlands | |
10:45 |
Coffee break |
11:15 |
Functional neuroimaging studies of studies of emotion processing |
| Dr Ruud Kortekaas, University of Groningen, The Netherlands | |
11:45 |
Elevated talk: Re-establishment of normal blood flow is mandatory to restore intramuscular |
| high energy phosphate levels after transient ischemia | |
| Dr Martin Andreas, Medical University of Vienna, Austria | |
12:00 |
Translatability of non-clinical and clinical imaging data to clinical efficacy |
| Dr Peter de Boer, Johnson & Johnson, Belgium | |
12:30 |
End of symposium |
Organiser: |
Professor Alison Gurney, University of Manchester, UK |
9:30 |
Deafness resulting from impaired inner ear K transport |
| Professor Thomas J Jentsch, Leibniz-Institut für Molekulare Pharmakologie , Germany | |
10:00 |
Elevated talk: A role for KCNQ channels in hypoxia-induced pulmonary vasoconstriction |
| and hypertension | |
| Dr Shreena Joshi, University of Manchester, UK | |
10:15 |
KCNQ Channels in Smooth Muscle |
| Dr Iain Greenwood, University of London, UK | |
10:45 |
Coffee break |
11:15 |
Neural KCNQ channels |
| Professor David Brown, University College, UK | |
11:45 |
Elevated talk: Functional effects of ether-á-go-go-related channel activators on murine vascular |
| smooth muscle | |
| Dr Shuk Yin Yeung, St Georges University of London, UK | |
12:00 |
Physiological and pharmacological regulation of Kv7 channels |
| Dr Soren-Peter Olesen, University of Copenhagen, Denmark | |
12:30 |
End of symposium |
Organisers: |
Dr Chris Langmead, GlaxoSmithKline, UK |
| Martyn Wood, GlaxoSmithKline, UK | |
9:30 |
Challenges of allosterism in drug discovery |
| Professor Arthur Christopoulous, Monash University, Australia | |
10:00 |
Elevated talk: The endocannabinoids anandamide and 2 arachadonylglcerol are negative |
| allosteric modulators of ligand binding at the human A3 adenosine receptor | |
| Dr Robert Lane , University of Leiden, The Netherlands | |
10:15 |
Mechanistic insights into allosteric modulation of NMDA receptors |
| Dr Pierre Paoletti, CNRS, France | |
10:45 |
Coffee break |
11:15 |
Developing Allosteric Modulators of GPCR’s |
| Dr Emmanuel LePoul, Addex Pharma SA, Switzerland | |
11:45 |
Elevated talk: Regulation of the M1 muscarinic acetylcholine receptor by orthosteric and |
| allosteric ligands | |
| Ms Rachel Thomas, University of Leicester, UK | |
12:00 |
Analysis of allosterism: How and when to look for positive modulation |
| Dr Chris Langmead, GlaxoSmithKline, UK | |
12:30 |
End of symposium |
