Organiser:	Professor Catherine Marchand-Leroux, University Paris 5, France
Speakers:	Nitric Oxide, Nitrosative Stress in the Pathogenesis of Diabetic Complications
	Professor Csaba Szabo, Semmelweis University, Hungary and University of Medicine and Dentistry of
	New Jersey, USA
	Modulation of NO Production by Tyrosine Phosphatase Inhibition in Cardiovascular Diseases
	Professor Vincent Richard, Rouen University Hospital, France
	Nitrosative Stress and Circulatory Shock
	Professor Salvatore Cuzzocrea, University of Messina, Italy
	Nitric Oxide/Nitrosative Stress Pathway in Brain Injury
	Dr Valerie Besson, University Paris Descartes, France

 

Organisers:	Dr Eamonn Kelly, University of Bristol, UK
	Professor Graeme Henderson, University of Bristol, UK
Speakers:	Professor Brian Kobilka, Stanford University , USA
	Professor Philip G Strange, University of Reading, UK
	Professor Michael Spedding, Institut de Recherche Servier, France
	Dr Chris P Bailey, University of Bath, UK

 

Organiser:	Dr Jean-Pierre Valentin, AstraZeneca, UK
Speakers:	Non-Clinical Strategies to address QT Liability and Proarrhythmic Risk
	Dr Chris Pollard, AstraZeneca, UK
	Value of Non-Clinical Repolarisation Assay Studies to Support Drug Discovery, Development,
	Regulatory Approval and Life Cycle Management
	Dr Jean-Pierre Valentin, AstraZeneca, UK
	Through QT/QTc Study: A Review Three Years after Implementation
	Dr Borje Darpo, Consultant, Sweden
	Drug Induced QT Shortening – Is it an Issue?
	Dr Rashmi Shah, Medical and Healthcare products Regulatory Agency, UK
	Integrated Risk Assessment and Predictive Value to Humans of Non-Clinical Repolarisation
	Assays
	Dr Rob Wallis, Pfizer, UK

 

Organisers:	Professor Ulf Simonsen, University of Aarhus, Denmark
	Dr Michel Feletou, Institut de Recherche Servier, France
Speakers:	K+ Channels and Release of EDHF
	Dr Gillian Edwards, University of Manchester, UK
	Role of K+ Channels in Restenosis and Angiogenesis
	Dr Ralf Kohler, Philipps-Universitat, Germany
	K+ Channels and Release of Nitric Oxide
	Dr Edgaras Stankevicius, University of Aarhus, Denmark
	K+ Channels and Endothelial Dysfunction - Therapeutic Option?
	Dr Michel Feletou, Institut de Recherche Servier, France

 

THE EUROPEAN HISTAMINE RESEARCH SOCIETY (EHRS) SYMPOSIUM

Organiser:	Dr Paul Chazot, University of Durham, UK
	Dr Ekaterini Tiligada, University of Athens, Greece
Chairs:	Professor Steve Hill, University of Nottingham, UK
	Professor Robin Ganellin, University College, UK
Speakers:	Histamine H3 Receptors in Psychiatric Diseases and Parkinson’s Disease
	Professor Pertti Panula, University of Helsinki, Finland
	Histamine Receptors: From the Human Genome to the New Therapeutic Options for Inflammatory
	Disorders
	Professor Rob Leurs, Vrije Universiteit Amsterdam, The Netherlands
	The H4 Receptor and Potential Cancer Therapy
	Professor Andras Falus, Semmelweis University, Hungary
	Histamine H3 Receptor Antagonists: From Target Identification to Clinical Candidate
	Professor Nicholas Carruthers, Johnson & Johnson, USA

 

Organiser:	Dr Sandra Siehler, Novartis, Switzerland
Speakers:	Physiological Relevance of Galpha12 and Galpha13 in Various Tissues
	Dr Stefan Offermanns, University of Heidelberg, Germany
	Role of G12/13 Signalling in Cancer Invasion and Metastasis
	Dr Patrick J Casey, University of Durham, UK
	Regulation of RhoGEF Proteins by Galpha12/13-Coupled Receptors, and Disease-Related Context
	Dr Sandra Siehler, Novartis, Switzerland
	Involvement of the G12-RhoGEF-Rho Pathway in Neurotransmitter Release of C. Elegans
	Dr Stephen J Nurrish, University College, UK

 

Organisers:	Professor Christopher Fowler, Umea University, Sweden
	Professor Roger Pertwee, University of Aberdeen, UK
Speakers:	Introduction to the Pharmacology of the Endocannabinoid System
	Professor Roger Pertwee, University of Aberdeen, UK
	Inhibition of Endocannabinoid Metabolism as a Strategy for the Treatment of Pain and Anxiety
	Professor Daniele Piomelli, University of California, USA
	The Endocannabinoid System as a Target for the Treatment of Motor Dysfunction
	Professor Javier Fernandez-Ruiz, Universidad Complutense, Spain
	Molecular Bases of the Therapeutic use of Antagonists of Endocannabinoid Action Against
	Metabolic Disorder
	Professor Vincenzo Di Marzo, National Research Council, Italy
	Novel Approaches to Targeting the Endocannabinoid System
	Dr Julia Adam, Organon Research, The Netherlands
	Perspectives and Future Strategies
	Professor Christopher Fowler, Umea University, Sweden

 

Organisers:	Professor Herman Meurs, University of Groningen, The Netherlands
	Professor Johan Zaagsma, University of Groningen, The Netherlands
Speakers:	Recent Advances in L-Arginine Metabolism
	Professor Sidney M Morris Jr, University of Pittsburgh, USA
	Regulation of Cationic Amino Acid Transport
	Professor Ellen I Cross, Johannes Gutenberg University, Germany
	Role of Arginase in the Immune System
	Dr Markus Munder, University of Heidelberg, Germany
	Arginase: A Novel Ney Enzyme in Asthma
	Dr Harm Maarsingh, University of Groningen, The Netherlands

 

Organiser:	George Karakiulakis, Aristotle University of Thessaloniki, Greece
Speakers:	Modifying the Wnt System as a Therapeutic Approach for Pulmonary Fibrosis
	Dr Oliver Eickelberg, University of Giessen, Germany
	Novel Therapeutic Targets in Pulmonary Arterial Hypertension
	Dr Nicholas W. Morell, University of Cambridge, UK
	The 'Sweet and Bitter' Involvement in Lung Diseases
	Dr Eleni Papakonstantinou, Aristotle University of Thessaloniki, Greece
	The Role of the Smooth Muscle Cell in Airway Remodelling in Asthma
	Dr Michael Roth, University of Sydney, Australia
	TGFβ Superfamily Signalling in Lung Development and Pathology
	Dr Pashalis Sideras, Academy of Athens, Greece

 

Organiser:	Finn Olav Levy, University of Oslo, Norway
Chairs:	Professor Jan-Bjørn Osnes, University of Oslo, Norway
	ProfessorFinn Olav Levy, University of Oslo, Norway
Speakers:	Mechanisms of Beneficial Effects of Beta-Adrenoceptor Blockade in Heart Failure
	Stefan Engelhardt, University of Wuerzburg, Germany
	Adrenoceptor Polymorphisms and Individualised Treatment of Heart Failure
	Kirsten Leineweber, University of Essen, Germany
	Dual Serotonergic Regulation of the Failing Cardiac Ventricle: Mechanisms and Possible
	Therapeutic Consequences
	Finn Olav Levy, University of Oslo, Norway
	Role of Myocardial Alpha1 – Adrenoceptors in Heart Failure
	Paul C Simpson, San Francisco VA Medical Centre, USA

 

Organiser:	Professor Ana Maria Sebastiao, University of Lisbon, Portugal
Speakers:	G Protein-Coupled Receptor Dimerization: Molecular Basis and Relevance for Function
	Professor Graeme Milligan, University of Glasgow, UK
	The Two State Dimer Model
	Professor Rafael Franco, University of Barcelona, Spain
	D1-D2 Hetero-oligomers with Unique Pharmacology
	Prof. Brian O’Dowd, University of Toronto, Canada
	Cross Talk between Tyrosine Kinase Receptors and GPCRs
	Professor Ana Maria Sebastiao, University of Lisbon, Portugal

 

Organisers:	Gillian Edwards, University of Manchester, UK
	Professor Martial Ruat, CNRS, France
Speakers:	Calcium, Allosteric Modulators and Calcium Sensing Receptor Activity
	Professor Martial Ruat, CNRS, France
	Calcium Sensing Receptors in the Vasculature: Pharmacology and Functions
	Professor Arthur Weston, University of Manchester, UK
	Pharmacology of GPRC6A and Related Receptors
	Professor Hans Brauner-Osborne, Danish University of Pharmaceutical Sciences, Denmark
	Calcimimetics for Hyperparathyroidism in Patients Receiving Haemodialysis
	Professor Tilman B Drueke MD, Necker Hospital, France

 

Organiser:	Dr Bastian Hengerer, Boehringer Ingelheim, Germany
Speakers:	Present Understanding of Neurodegenerative Mechanisms in Parkinson’s Disease
	Professor Peter Jenner, Kings College, UK
	Non-Human Primate Models of Motor and Non-Motor Symptoms of Parkinson’s Disease
	Prof. Erwan Bezard, University of Bordeaux 2, France
	Cell Models of Genetic Parkinson’s Disease for Testing Neuroprotective Therapeutic Agents
	Prof. Christopher Ross, Johns Hopkins University, USA
	Exogenous Modulation of Adult Neurogenesis in Preclinical Models of Parkinson’s Disease
	Prof. Jürgen Winkler, University of Regensberg, Germany

 

Organisers:	Paul M Vanhoutte, University of Hong Kong, China
	Michel Feletou, Institut de Recherche Servier, France
Speakers:	Uridine Adenosine-Tetraphosphate: A New Endothelium-Derived Contracting Factor
	Joachim Jankowski, Charite-Universitaetsmedizin Berlin, Germany
	Endothelium-Dependent Contractions and the Prostanoid TP Receptor
	Michel Feletou, Institut de Recherche Servier, France
	Endothelium-Dependent Contractions and Endothelial Dysfunction in Human Essential
	Hypertension
	Professor Stefano Taddei, University of Pisa, Italy
	Endothelin Receptor Antagonists and Cardiovascular Diseases
	Prof David J Webb, University of Edinburgh, UK

 

Organiser:	Pavel Anzenbacher, Palacky University, Czech Republic
Speakers:	Cytokine Blockade: a Major Movement in Translational Medical Research
	Dr Marc Feldmann, Imperial College, UK
	Screening for Cytokine-Stimulatory Potential of Drugs - Why and How
	Dr Zdenek Zidek, Academy of Sciences, Czech Republic
	Immunoregulatory Role of Histamine
	Dr C A Akdis, Weiss Institute, Switzerland
	Intolerance to Tolerability. Data Intensive Early Phase Drug Studies in Man - the Key to
	Translational Development
	Dr Adam Cohen, Leiden University, The Netherlands

 

Organiser:	Prof Eeva Moilanen, University of Tampere, Finland
Speakers:	Transporters in the Cardiovascular System: Physiological and Pharmacological Functions
	Professor Heyo K Kroemer, Ernst Moritz Arndt University, Germany
	The Role of Serotonin Transporters in Pulmonary Haemodynamics
	Professor Margaret MacLean, University of Glasgow, UK
	Impact of OATP Transporters on Drug Disposition
	Dr Nikko Niemi, University of Helsinki, Finland
	Drug Transporters in the Human Blood-Placental Barrier
	Professor Kirsi Vahakangas, University of Kuopio, Finland

 

Organiser:	Prof Martina Schmidt, University of Groningen, The Netherlands
Speakers:	The Role of Epac1 in Endothelial Cell-Cell Junction Formation
	Professor Johannes L Bos, UMC Utrecht, The Netherlands
	Compartmentalized cAMP Signalling in Cardiac Myocytes
	Dr Manuela Zaccolo, University of Glasgow, UK
	Regulation of Anti-Inflammatory Signalling by Epac in Vascular Endothelial Cells
	Dr Stephen Yarwood, University of Glasgow, UK
	Epac in Airway Development and Biology
	Prof Martina Schmidt, University of Groningen, The Netherlands

 

Organiser:	Izaak Den Daas, Xendo Drug Development B.V, The Netherlands
Speakers:	Molecular Imaging of Gene Expression in the Living
	Biotherapies
	Dr Georges Vassaux, Institut des Maladies de l’Appareil Digestif 1, France
	Positron Emission Tomography: the Conceptual Idea Using a Multi Disciplinary Approach
	Dr Anne M.J Paans, University Medical Centre Groningen, The Netherlands
	Functional Neuroimaging Studies of Studies of Emotion Processing
	Dr Andre Aleman, University of Groningen, The Netherlands
	Neuroimaging as a Tool in Early Drug Development and Experimental Medicine
	Dr Peter de Boer, Johnson & Johnson, Belgium

 

Organiser:	Professor Alison Gurney, University of Manchester, UK
Speakers:	KCNQ4 Channels and Progressive Hearing Loss
	Professor Thomas J Jentsch, Leibniz-Institut für Molekulare Pharmakologie , Germany
	KCNQ Channels in Smooth Muscle
	Dr Iain Greenwood, University of London, UK
	Neuronal KCNQ Channels
	Professor David Brown, University College, UK
	KCNQ Channel Modulators
	Dr Soren-Peter Olesen, University of Copenhagen, Denmark

 

Organisers:	Dr Chris Langmead, GlaxoSmithKline, UK
	Martyn Wood, GlaxoSmithKline, UK
Speakers:	Overview of Allosterism in Drug Discovery
	Professor Arthur Christopoulous, Monash University, Australia
	Developing Allosteric Modulators of Ion Channels
	Dr Pierre Paoletti, CNRS, France
	Developing Allosteric Modulators of GPCR’s
	Dr Emmanuel LePoul, Addex Pharma SA, Switzerland
	Assay Design and Data Analysis
	Dr Chris Langmead, GlaxoSmithKline, UK